USP35

ubiquitin specific peptidase 35

Ensembl:: ENSG00000118369
UniProt:: Q9P2H5
OMIM:: 620959
Synonyms:: KIAA1372

Cilia effects upon perturbation of USP35

Ciliogenesis screen results (2 screens)

Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:: shortened qt interval
Mouse ciliopathy phenotype:: prolonged qrs complex duration

Subcellular localization

cilia associated gene

Functional category

Ciliary assembly/disassembly
Trafficking (BBSome, small GTPases, vesicular transport, ATPases)

Function

USP35 (and its orthologue USP38) showed that suppression or ablation in vivo rescued a host of ciliopathy-associated a tomical pathologies, with concomitant rescue of the overabundance of key sig ling molecules ( 31723061).

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