USP7

ubiquitin specific peptidase 7

Ensembl:
ENSG00000187555
UniProt:
Q93009
OMIM:
602519
Synonyms:
HAUSP

Cilia effects upon perturbation of USP7

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-2.16) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

cilia associated gene, nuclear bodies, nucleoplasm

Functional category

  • Non-motile cilium / primary cilium; Signaling (Hedgehog, GPCRs, ion channels)

Function

USP7 is a cilia-associated deubiquitinating enzyme that interacts with the EVC–EVC2 complex and participates in primary cilium–dependent Hedgehog signaling, a pathway disrupted in Ellis–van Creveld syndrome (PMID: 37576597).