VASH2

vasohibin 2

Tier: Cilia-Associated Genes

Ensembl:: ENSG00000143494
OMIM:: 610471
Synonyms:: FLJ12505

Subcellular localization

Cytosol

References: PMID:39865093

Functional category

Metabolism
Non-motile cilium / primary cilium
Cilia–cytoskeleton/adhesion links

Function

We test whether tubulin detyrosination (enriched on B-tubules) and tyrosination (enriched on A-tubules) have a role in IFT logistics. We report that knockout of tubulin detyrosinase VashL in Chlamydomonas reinhardtii causes frequent IFT train stoppages and impaired ciliary growth. By reconstituting IFT train motility on de-membranated axonemes and synthetic microtubules, we show that anterograde and retrograde trains preferentially associate with detyrosinated and tyrosinated microtubules, respectively. We propose that tubulin tyrosination/detyrosination is crucial for spatial segregation and collision-free IFT train motion, highlighting the significance of the tubulin code in ciliary transport(39865093).

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