VCAN

versican

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000038427
UniProt:: P13611
OMIM:: 118661
Synonyms:: CSPG2, PG-M

Ciliogenesis screen results (2 screens)

Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Phenotypes

Mouse phenotype:: embryonic growth retardation, abnormal eye morphology, abnormal placenta morphology, abnormal somite shape, abnormal optic vesicle formation, abnormal visceral yolk sac morphology, enlarged spleen, abnormal heart looping, abnormal pharyngeal arch morphology, preweaning lethality, complete penetrance, abnormal vitelline vasculature morphology, pretal lethality prior to heart atrial septation, abnormal neural tube morphology, abnormal spleen morphology

Subcellular localization

flagella

References: PMID:25613900

Functional category

Neurogenesis & migration
Cell migration & adhesion
Signaling (Hedgehog, GPCRs, ion channels)

Function

VCAN localized to flagella (25613900)

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