VCAN

Cilia effects upon perturbation of VCAN

Ciliogenesis screen results (2 screens)

• Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
• Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Phenotypes

Mouse phenotype:

embryonic growth retardation, abnormal eye morphology, abnormal placenta morphology, abnormal somite shape, abnormal optic vesicle formation, abnormal visceral yolk sac morphology, enlarged spleen, abnormal heart looping, abnormal pharyngeal arch morphology, preweaning lethality, complete penetrance, abnormal vitelline vasculature morphology, pretal lethality prior to heart atrial septation, abnormal neural tube morphology, abnormal spleen morphology

Mouse ciliopathy phenotype:

microphthalmia, abnormal heart morphology, persistence of hyaloid vascular system, eye hemorrhage, abnormal reti morphology, abnormal embryo turning

Subcellular localization

flagella

Functional category

• Neurogenesis & migration
• Cell migration & adhesion
• Signaling (Hedgehog, GPCRs, ion channels)

Function

VCAN localized to flagella (25613900)