VCP

Cilia effects upon perturbation of VCP

Cilia number / % ciliated:

Decrease

Loss-of-function effect:

Shorter cilia

Ciliogenesis screen results (4 screens)

• Kim2016: Not Reported
• Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-24.23) PMID:26167766
• Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
• Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

cilia, endoplasmic reticulum, ciliary tip, transition zone, basal body

References: PMID:41005307, PMID:26389662

Functional category

• Ciliary assembly/disassembly
• Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
• Actin & cytoskeleton regulation
• Metabolism
• Viral interactions
• Protein processing & maturation
• Signaling (Hedgehog, GPCRs, ion channels)
• Transition zone

Function

Regulator of protein quality control and ubiquitin-mediated signaling. Interacts wiith UBXN10 to control its localisation to cilia. VCP and UBXN10 interaction is also required for ciliogenesis and maintenance of cilia (26389662). VCP localizes to primary cilia; its inhibition reduces cilia length and affects cilia assembly. VCP inhibition reduces cyst burden in Pkd1-KO mice. Connects proteostasis and ciliary dynamics.