VDAC1

voltage dependent anion channel 1

Ensembl:
ENSG00000213585
UniProt:
P21796
OMIM:
604492
Synonyms:
MGC111064, PORIN

Cilia effects upon perturbation of VDAC1

Cilia number / % ciliated:
Incrased cilia number
Loss-of-function effect:
Longer cilia
Overexpression effect:
Decreased

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:
impaired glucose tolerance, increased startle reflex, preweaning lethality, incomplete penetrance

Subcellular localization

basal body, mitochondria, nucleus

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

Centrosomal VDAC1 is predomi ntly localized to the mother centriole, while VDAC2 localizes to centriolar satellites in a microtubule-dependent manner. Down-regulation of VDAC1 leads to i ppropriate ciliogenesis, while its overexpression suppresses cilia formation(26264029).