VDAC3

Cilia effects upon perturbation of VDAC3

Cilia number / % ciliated:

Incrased cilia number

Loss-of-function effect:

Longer cilia

Overexpression effect:

Decreased

Ciliogenesis screen results (3 screens)

• Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-5.04) PMID:26167766
• Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
• Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:

abnormal coat appearance

Mouse ciliopathy phenotype:

abnormal liver morphology

Subcellular localization

cilia, mitochondria, nucleus

Functional category

• Ciliary assembly/disassembly
• Actin & cytoskeleton regulation
• T cell biology
• Reproduction & sperm
• Cell migration & adhesion
• Signaling (Hedgehog, GPCRs, ion channels)

Function

Required for the mainte nce of axonemes of sperm, absence of VDAC3 in the mouse leads to defective axonemal structures in sperm and immotility (11507092). Modulates centriole assembly by recruites Mps1 to centrosomes. VDAC3-Mps1 interaction promotes ciliary disassembly during cell cycle entry and prevents cilia assembly in proliferating cells (23388454, 26264029).