VIPR2

vasoactive intestinal peptide receptor 2

Ensembl:
ENSG00000106018
UniProt:
P41587
OMIM:
601970
Synonyms:
VPAC2, VPAC2R

Cilia effects upon perturbation of VIPR2

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-6.03) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

cilia

Functional category

  • Ciliary assembly/disassembly
  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Ciliary membrane
  • Cardiac & muscle development

Function

VPAC2 ciliary targeting is dependent on Tubby, the BBSome (a complex of Bardet鈥揃iedl syndrome proteins) and the BBSome targeting factor, Arl6 (25369807)., Vasoactive Intesti l Peptide Receptor 2 (VPAC2, also known as VIPR2) localizes to primary cilia not only in neurons but also in glial cells, including astrocytes and oligodendrocyte lineage cells. The C-terminus of VPAC2 is sufficient to target a non-ciliary membrane protein to cilia, and the BBSome (a complex of Bardet鈥揃iedl syndrome proteins), the BBSome targeting factor Arl6 and Tubby are important for ciliary targeting of endogenous VPAC2(25369807).