VPS11

VPS11 core subunit of CORVET and HOPS complexes

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000280616
UniProt:: Q9H270
OMIM:: 608549
Synonyms:: PEP5, RNF108

Ciliogenesis screen results (4 screens)

Kim2016: Not Reported
Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-8.44) PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: Positive Regulator (Hh signaling, casTLE effect=-2.39) PMID:29459680
Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:: preweaning lethality, complete penetrance

Subcellular localization

basal body

References: PMID:33561422

Functional category

Ciliary assembly/disassembly
Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
Viral interactions
Signaling (Hedgehog, GPCRs, ion channels)
Ciliary membrane

Function

The HOPS complex is a RAB19 effector functioning in CC and ciliogenesis through a non-lysosomal pathway. VPS41 and VPS11 co-precipitate with the C-terminus of TBC1D4 and this binding is significantly decreased in RAB19 KO cells. RAB19 recruits the HOPS complex to the centrosome and mediates interaction with TBC1D4 to coordinate CC and ciliary membrane growth during primary ciliogenesis(33561422).

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