VPS11

VPS11 core subunit of CORVET and HOPS complexes

Ensembl:
ENSG00000280616, ENSG00000160695
UniProt:
Q9H270
OMIM:
608549
Synonyms:
PEP5, RNF108

Cilia effects upon perturbation of VPS11

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-8.44) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: Positive Regulator (Hh signaling, casTLE effect=-2.39) PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:
preweaning lethality, complete penetrance

Subcellular localization

basal body

Functional category

  • Ciliary assembly/disassembly
  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
  • Viral interactions
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Ciliary membrane

Function

The HOPS complex is a RAB19 effector functioning in CC and ciliogenesis through a non-lysosomal pathway. VPS41 and VPS11 co-precipitate with the C-terminus of TBC1D4 and this binding is significantly decreased in RAB19 KO cells. RAB19 recruits the HOPS complex to the centrosome and mediates interaction with TBC1D4 to coordi te CC and ciliary membrane growth during primary ciliogenesis(33561422).