VPS37A

VPS37A subunit of ESCRT-I

Ensembl:
ENSG00000155975
UniProt:
Q8NEZ2
OMIM:
609927
Synonyms:
FLJ32642, HCRP1, PQBP2, SPG53

Cilia effects upon perturbation of VPS37A

Ciliogenesis screen results (2 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-3.83) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Phenotypes

Mouse phenotype:
decreased body length, preweaning lethality, complete penetrance, abnormal embryo size, abnormal coat/ hair morphology, increased freezing behavior

Subcellular localization

basal body, centrosome, flagella, nucleus

Functional category

  • Ciliary assembly/disassembly
  • Viral interactions

Function

VPS37A has localized in basal body,flagella.