VPS39

VPS39 subunit of HOPS complex

Ensembl:
ENSG00000166887
UniProt:
Q96JC1
OMIM:
612188
Synonyms:
KIAA0770, VAM6

Cilia effects upon perturbation of VPS39

Cilia number / % ciliated:
Decreased cilia number
Loss-of-function effect:
Longer Cilia/Shorter Cilia
Overexpression effect:
Decreased, Not Reported

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-2.18) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: Positive Regulator (Hh signaling, casTLE effect=-2.82) PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

cilia associated gene, endosome

Functional category

  • Ciliary assembly/disassembly
  • Viral interactions

Function

The HOPS complex subunit VPS39 controls ciliogenesis through autophagy ( 32077937).