WBP11

WW domain binding protein 11

Ensembl:
ENSG00000084463
UniProt:
Q9Y2W2
OMIM:
618083
Synonyms:
BUG13, NPWBP, PPP1R165, SIPP1

Cilia effects upon perturbation of WBP11

Ciliogenesis screen results (5 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-14.06) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: Increased Signaling (Negative Regulator) PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Pusapati et al. 2018 (CRISPR) [CRISPR]: Positive Regulator (Hh signaling, neg_rank=592, lfc=-2.36) PMID:30270045

Phenotypes

Human ciliopathy phenotype:
vertebral, cardiac, tracheoesophageal, renal, and limb defects

Subcellular localization

flagella, nucleus

Function

WBP11 has localized in flagella.