WDR18

WD repeat domain 18

Ensembl:
ENSG00000065268
UniProt:
Q9BV38
OMIM:
620291
Synonyms:
IPI3

Cilia effects upon perturbation of WDR18

Cilia number / % ciliated:
Decreased cilia number
Loss-of-function effect:
Shorter cilia

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-2.90) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: Increased Signaling (Negative Regulator) PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:
preweaning lethality, complete penetrance, limb grasping

Subcellular localization

basal body, cilia, nucleus

Functional category

  • Ciliary assembly/disassembly

Function

Wdr18 is required for Kupffer's vesicle formation and regulation of body asymmetry in zebrafish ( 21876750).