WDR27
WD repeat domain 27
Tier: Gold Standard Ciliary Genes
- Ensembl:
- ENSG00000184465
- UniProt:
- A2RRH5
- OMIM:
- 620936
- Synonyms:
- MGC43690
Ciliogenesis screen results (2 screens)
- Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
- Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Phenotypes
- Mouse phenotype:
- increased red blood cell distribution width, decreased circulating cholesterol level, increased cardiac output, increased circulating iron level, decreased circulating hdl cholesterol level, enlarged spleen, abnormal spleen morphology
Subcellular localization
basal body, lysosomes, nucleus
References: PMID:28460059
Functional category
- Ciliary assembly/disassembly
Function
WDR27 colocalize with cilia in HK2 cells(28460059).