WDR27

Cilia effects upon perturbation of WDR27

Ciliogenesis screen results (2 screens)

• Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
• Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Phenotypes

Mouse phenotype:

increased red blood cell distribution width, decreased circulating cholesterol level, increased cardiac output, increased circulating iron level, decreased circulating hdl cholesterol level, enlarged spleen, abnormal spleen morphology

Mouse ciliopathy phenotype:

increased circulating aspartate transamise level, thick ventricular wall, dilated aorta, abnormal reti morphology

Subcellular localization

basal body, lysosomes, nucleus

Functional category

• Ciliary assembly/disassembly

Function

WDR27 colocalize with cilia in HK2 cells(28460059).