WDR31

WD repeat domain 31

Ensembl:: ENSG00000148225
UniProt:: Q8NA23
OMIM:: 620951
Synonyms:: FLJ35921

Cilia effects upon perturbation of WDR31

Cilia number / % ciliated:: Decreased cilia number
Loss-of-function effect:: No effect
Overexpression effect:: No effect

Ciliogenesis screen results (3 screens)

Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-4.08) PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

cilia

Functional category

Ciliary assembly/disassembly
Trafficking (BBSome, small GTPases, vesicular transport, ATPases)

Function

WDR-31, together with RP-2 and ELMD-1 results in ciliary accumulations of IFT Complex B components and KIF17 kinesin, with fewer IFT/BBSome particles traveling along cilia in both anterograde and retrograde directions, suggesting that the IFT/BBSome entry into the cilia and exit from the cilia are impacted(37208194).

Model organism evidence

Danio rerio (1 reference)

WDR31 displays functional redundancy with GTPase-activating proteins (GAPs) ELMOD and RP2 in regulating IFT complex and recruiting the BBSome to cilium.

PMIDs: 37208194

C. elegans (1 reference)

WDR31 displays functional redundancy with GTPase-activating proteins (GAPs) ELMOD and RP2 in regulating IFT complex and recruiting the BBSome to cilium.

PMIDs: 37208194

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