WDR4

WDR4 tRNA N7-guanosine methyltransferase non-catalytic subunit

Ensembl:: ENSG00000160193
UniProt:: P57081
OMIM:: 605924
Synonyms:: TRM82, TRMT82, WUHO

Cilia effects upon perturbation of WDR4

Cilia number / % ciliated:: Decreased cilia number
Loss-of-function effect:: Shorter cilia

Ciliogenesis screen results (3 screens)

Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-2.79) PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: Positive Regulator (Hh signaling, casTLE effect=-1.17) PMID:29459680
Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Human ciliopathy phenotype:: microcephaly, growth deficiency, seizures, and brain malformations

Subcellular localization

basal body, cilia, nucleus

Functional category

Ciliary assembly/disassembly
Neurogenesis & migration

Function

WDR4 loss-of-function impairs head growth and neurogenesis via aberrant cilia formation, initially caused by disturbed protein and ubiquitin homeostasis ( 39251572).

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