WDR49

WD repeat domain 49

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000174776
UniProt:: Q8IV35
Synonyms:: FLJ33620

Ciliogenesis screen results (1 screens)

Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Phenotypes

Mouse phenotype:: abnormal skin morphology

Subcellular localization

basal body, ciliary tip, cilia, transition zone

References: PMID:41005307, PMID:39743588

Functional category

Ciliary assembly/disassembly

Function

WDR49 has localized in cilia. Identified by cryo-EM as an external microtubule-associated protein of the doublet microtubules in respiratory, oviductal and ependymal cilia (Leung et al., 2025, Nature, PMID 39743588).

Note: Additional interactive sections (perturbation matrix visualization, phylogenetic conservation strip, protein complex network, STRING interactions) require JavaScript. Browse CiliaHub for the full experience.