WDR5

WD repeat domain 5

Ensembl:
ENSG00000196363
UniProt:
P61964
Synonyms:
BIG-3, CFAP89, SWD3

Cilia effects upon perturbation of WDR5

Cilia number / % ciliated:
Decreased cilia number
Loss-of-function effect:
Shorter cilia

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-21.18) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: Increased Signaling (Negative Regulator) PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

cilia, nucleus

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • Transcription regulation

Function

Stabilizes actin architecture to promote multiciliated cell formation (30205038). Regulates FOXJ1 expression to control ciliogenesis at the node and LR patterning. De novo change in patient with CHD and heterotaxy (30377171)

Model organism evidence

Xenopus (1 reference)

Here, we show that Wdr5 depletion leads to LR patterning defects in Xenopus via its role in ciliogenesis.

PMIDs: 30377171