WDR54

WD repeat domain 54

Ensembl:
ENSG00000005448
UniProt:
Q9H977
OMIM:
620826
Synonyms:
FLJ12953

Cilia effects upon perturbation of WDR54

Cilia number / % ciliated:
No effect
Loss-of-function effect:
Longer cilia
Overexpression effect:
No effect

Ciliogenesis screen results (2 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Subcellular localization

basal body, cilia, flagella

Functional category

  • Ciliary assembly/disassembly
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

WDR54 is indeed in the cilia of human RPE1 cells and WDR54 localize to the cilia of sensory neurons of the head and tails in C. elegans(38989623).