WFDC2

Cilia effects upon perturbation of WFDC2

Cilia number / % ciliated:

Unknown

Loss-of-function effect:

Shorter cilia

Overexpression effect:

Unknown

Ciliogenesis screen results (4 screens)

• Kim2016: Not Reported
• Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
• Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
• Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:

decreased eosinophil cell number, increased circulating amylase level, preweaning lethality, incomplete penetrance

Mouse ciliopathy phenotype:

enlarged heart

Subcellular localization

cilia associated gene

Functional category

• Ciliary assembly/disassembly

Function

Deleting Wfdc2 in mice causes perinatal death due to respiratory failure soon after birth. Wfdc2-deficient neonatal mice have lung atelectasis of variable magnitude and at various locations. This phenotype is likely caused by damage to cilia, elimination of mature club cells in the tracheobronchial region and impairment of the processing of surfactants in AECIIs. Taken together, these results suggest that, in vivo, Wfdc2 plays critical roles in multiple aspects of lung function: it not only promotes mucociliary clearance but also confers anti-inflammatory activity and reduces surface tension(PMID: 31562139).