WIF1

WNT inhibitory factor 1

Ensembl:
ENSG00000156076
UniProt:
Q9Y5W5
OMIM:
605186

Cilia effects upon perturbation of WIF1

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

cilia associated gene

Functional category

  • Ciliary assembly/disassembly
  • T cell biology
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

Microarray a lysis of NP and IT tissues revealed differential gene expression of Wnt pathway genes revealed that down-regulation of the Wnt inhibitor WIF1and differential expression of several target genes of Wnt/β-catenin sig ling, such as WISP1 by ( 28059551).

Model organism evidence

Mus musculus (1 reference)

Remodelling of supernumerary leaflet primordia leads to bicuspid aortic valve caused by loss of primary cilia.

PMIDs: 40498626