WIF1

WNT inhibitory factor 1

Tier: Cilia-Associated Genes

Ensembl:: ENSG00000156076
UniProt:: Q9Y5W5
OMIM:: 605186

Ciliogenesis screen results (4 screens)

Kim2016: Not Reported
Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

No ciliary localization reported (cilia-associated gene).

References: PMID:28059551

Functional category

Ciliary assembly/disassembly
Signaling (Hedgehog, GPCRs, ion channels)

Function

Microarray analysis of NP and IT tissues revealed differential gene expression of Wnt pathway genes revealed that down-regulation of the Wnt inhibitor WIF1and differential expression of several target genes of Wnt/β-catenin signaling, such as WISP1 by ( 28059551).

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