WNT1
Wnt family member 1
- Ensembl:
- ENSG00000125084
- UniProt:
- P04628
- OMIM:
- 164820
- Synonyms:
- INT1
Cilia effects upon perturbation of WNT1
Ciliogenesis screen results (4 screens)
- Kim2016: No effect
- Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
- Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
- Roosing et al. 2015 (siRNA) [siRNA]: Hyper-ciliogenesis (robust z=2.18, ciliated=54.3%) PMID:26595381
Phenotypes
- Mouse phenotype:
- preweaning lethality, incomplete penetrance, preweaning lethality, complete penetrance, increased circulating cholesterol level
- Mouse ciliopathy phenotype:
- increased circulating creatinine level
Subcellular localization
cilia associated gene, lysosomes
Functional category
- Ciliary assembly/disassembly
- Actin & cytoskeleton regulation
- T cell biology
- Protein processing & maturation
- Cell migration & adhesion
- Signaling (Hedgehog, GPCRs, ion channels)
- Cardiac & muscle development
- Transcription regulation
Function
Using the Kif3af/f ,Wnt1-Cre ciliopathic mouse model to prevent Shh sig l transduction by means of the loss of primary cilia in neural crest cells, mesenchymal Shh activity is necessary for gland development ( 29532549).
Model organism evidence
Mus musculus (2 references)
METHODS AND RESULTS: Here, we disrupted primary cilia by deleting the ciliary gene Ift88 in the main progenitor cells forming the aortic valve using specific Cre drivers: Wnt1-Cre for neural crest cells, Isl1-Cre for second heart field (SHF) cells, Tie2-Cre for endocardial-derived cells, and Tnnt
Primary Cilium in Neural Crest Cells Crucial for Anterior Segment Development and Corneal Avascularity.