WNT11

Wnt family member 11

Ensembl:
ENSG00000085741
UniProt:
O96014
OMIM:
603699

Cilia effects upon perturbation of WNT11

Ciliogenesis screen results (2 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Phenotypes

Mouse phenotype:
decreased body length, increased blood urea nitrogen level
Mouse ciliopathy phenotype:
small testis, abnormal kidney morphology, abnormal testis morphology

Subcellular localization

cilia associated gene

Functional category

  • Ciliary assembly/disassembly
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Cardiac & muscle development
  • ECM & connective tissue
  • Transcription regulation

Function

Nlz1 contributes to motile cilia formation by positively regulating Wnt11/presumed non-canonical Wnt sig ling ( 26327644).

Model organism evidence

C. elegans (1 reference)

Primary cilia are located at the dendritic tips of sensory neurons and house the molecular machinery necessary for detection and transduction of sensory stimuli.

PMIDs: 33460640

Danio rerio (3 references)

Furthermore, Nlz1 contributes to motile cilia formation by positively regulating Wnt11/presumed non-canonical Wnt signaling.

Laterality was randomized in the brain, heart and viscera, likely a consequence of shorter cilia with disrupted axonemes and perturbed intravesicular fluid flow in Kupffer's vesicle.

PMIDs: 26327644, 18971206, 17906624

Mus musculus (3 references)

Remarkably, in addition to cyst formation, loss of primary cilia in the ureteric epithelial cell leads to decreased expression of Wnt11 and Ret and reduced ureteric branching.

This was preceded by excessive cell proliferation and apoptosis, and accompanied by disrupted ciliogenesis within the ureteric bud epithelium.

PMIDs: 23762375, 20944551, 18971206