WNT11

Wnt family member 11

Tier: Cilia-Associated Genes

Ensembl:
ENSG00000085741
UniProt:
O96014
OMIM:
603699

Ciliogenesis screen results (2 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Phenotypes

Mouse phenotype:
decreased body length, increased blood urea nitrogen level

Subcellular localization

No ciliary localization reported (cilia-associated gene).

References: PMID:26327644

Functional category

  • Ciliary assembly/disassembly
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Cardiac & muscle development
  • ECM & connective tissue
  • Transcription regulation

Function

Nlz1 contributes to motile cilia formation by positively regulating Wnt11/presumed non-canonical Wnt signaling ( 26327644).