WNT3
Wnt family member 3
- Ensembl:
- ENSG00000277641, ENSG00000277626, ENSG00000108379
- UniProt:
- P56703
- OMIM:
- 165330
- Synonyms:
- INT4, MGC131950, MGC138321, MGC138323
Cilia effects upon perturbation of WNT3
- Cilia number / % ciliated:
- Decreased cilia number
- Overexpression effect:
- No effect
Ciliogenesis screen results (5 screens)
- Kim2016: No effect
- Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-3.53) PMID:26167766
- Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
- Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
- Failler/Valderrama et al. 2021 (siRNA) [siRNA]: Negative Regulator (Ciliogenesis Candidate) PMID:33206585
Phenotypes
- Mouse phenotype:
- preweaning lethality, complete penetrance
Subcellular localization
cilia associated gene
Functional category
- Ciliary assembly/disassembly
- Neurogenesis & migration
- Signaling (Hedgehog, GPCRs, ion channels)
- Axon guidance & growth
Function
WNT3A may also act by increasing the number, strength, or coherence of beating cilia ( 36878953).
Model organism evidence
Mus musculus (2 references)
Mouse Zfp423 mutants display a marked reduction of the hindbrain ChP (hChP), which: (1) fails to express established markers of its secretory function and genes implicated in its development and maintenance (Lmx1a and Otx2); (2) shows a perturbed expression of signaling pathways previously unexp
Whereas the basal body was normally positioned in the node cells of Wnt3a(-/-) embryos, inhibition of Rac1, a component of the noncanonical Wnt signalling pathway, impaired the polarized localization of the basal body in wild-type embryos.