WNT3A
Wnt family member 3A
- Ensembl:
- ENSG00000154342
- UniProt:
- P56704
- OMIM:
- 606359
Cilia effects upon perturbation of WNT3A
- Cilia number / % ciliated:
- Decreased cilia number
- Overexpression effect:
- No effect
Ciliogenesis screen results (3 screens)
- Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
- Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
- Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
Phenotypes
- Mouse phenotype:
- rib fusion, increased eosinophil cell number, abnormal spleen morphology, vertebral transformation, abnormal rib morphology, abnormal vertebral arch morphology, increased circulating triglyceride level, abnormal coat appearance, abnormal coat/ hair morphology, preweaning lethality, complete penetrance, abnormal vertebrae morphology, vertebral fusion
- Mouse ciliopathy phenotype:
- enlarged heart, abnormal reti vasculature morphology, abnormal heart morphology
Subcellular localization
cilia
Functional category
- Ciliary assembly/disassembly
- Actin & cytoskeleton regulation
- T cell biology
- Neurogenesis & migration
- Cell migration & adhesion
- Signaling (Hedgehog, GPCRs, ion channels)
- Cardiac & muscle development
- Axon guidance & growth
- Transcription regulation
Function
Wnt3a may also modulate the symmetry-breaking activity of mechanosensory cilia in the node. Wnt3a links the segmentation clock and AP axis elongation with key left-determining events, suggesting that Wnt3a is an integral component of the trunk organizer ( 16291790). Wnt3a treatment promotes primary ciliogenesis in hTERT-RPE cells ( 32023461).
Model organism evidence
Mus musculus (1 reference)
The mechanisms of Prdx5 deficiency mediated cyst growth include: (1) induction of oxidative stress as indicated by increased mRNA expression of heme oxygenase-1, an oxidant stress marker; (2) activation of Erk, S6 and mTORC1, which contribute to cystic renal epithelial cell proliferation and cys
PMIDs: 34888938