WNT5B

Wnt family member 5B

Ensembl:
ENSG00000111186
UniProt:
Q9H1J7
OMIM:
606361

Cilia effects upon perturbation of WNT5B

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-4.41) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:
increased bone mineral content, increased bone mineral density

Subcellular localization

cilia associated gene

Functional category

  • Ciliary assembly/disassembly
  • T cell biology
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Cardiac & muscle development
  • ECM & connective tissue

Function

Opposing gradients of Wnt5a and Wnt5b and of their Sfrp inhibitors, together with intercellular sig ling via PCP proteins, polarize node cells along the anterior-posterior axis for breaking of left-right symmetry ( 28292423).