WNT8A

Wnt family member 8A

Ensembl:
ENSG00000061492
UniProt:
Q9H1J5
OMIM:
606360
Synonyms:
WNT8D

Cilia effects upon perturbation of WNT8A

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-3.47) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

basal body

Functional category

  • Ciliary assembly/disassembly
  • T cell biology
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

Wnt8a R levels were increased in EFHC1b morphant ectodermal explants and intact embryos, a lyzed prior to the on-set of ciliogenesis ( 26783883).

Model organism evidence

Xenopus (2 references)

Wnt8a RNA levels were increased in EFHC1b morphant ectodermal explants and intact embryos, analyzed prior to the on-set of ciliogenesis.

Wnt signaling and ciliogenesis are core features of embryonic development in a range of metazoans.

PMIDs: 26783883, 25220153

Danio rerio (2 references)

Prompted by our recent discovery that Wnt signaling regulates ciliogenesis in the zebrafish Kupffer's vesicle (KV) via Foxj1a, a ciliogenic transcription factor, we decided to elucidate functions of Foxj1a in Wnt-regulated LR pattern formation.

nlz1 is required for cilia formation in zebrafish embryogenesis.

PMIDs: 26432885, 26327644

Mus musculus (1 reference)

Wnt signaling and ciliogenesis are core features of embryonic development in a range of metazoans.

PMIDs: 25220153

Drosophila (1 reference)

Wnt signaling and ciliogenesis are core features of embryonic development in a range of metazoans.

PMIDs: 25220153