WRAP73

WD repeat containing, antisense to TP73

Tier: Cilia-Associated Genes

Ensembl:: ENSG00000116213
UniProt:: Q9P2S5
OMIM:: 606040
Synonyms:: WDR8

Cilia effects upon perturbation of WRAP73

Cilia number / % ciliated:: Decreased cilia number
Loss-of-function effect:: Shorter cilia

Ciliogenesis screen results (3 screens)

Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-3.01) PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Pusapati et al. 2018 (CRISPR) [CRISPR]: Positive Regulator (Hh signaling, neg_rank=657, lfc=-2.02) PMID:30270045

Subcellular localization

centrosome

References: PMID:26675238

Functional category

Ciliary assembly/disassembly
Actin & cytoskeleton regulation

Function

WDR8. Centriolar satellite and centriole-associated protein. Interacts with centriolar satellite proteins SSX2IP and PCM1 and centriolar proximal end component Cep135. Promotes ciliary vesicle docking during ciliogenesis. (26675238).

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