WRAP73

WD repeat containing, antisense to TP73

Ensembl:
ENSG00000116213
UniProt:
Q9P2S5
OMIM:
606040
Synonyms:
WDR8

Cilia effects upon perturbation of WRAP73

Cilia number / % ciliated:
Decreased cilia number
Loss-of-function effect:
Shorter cilia

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-3.01) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Pusapati et al. 2018 (CRISPR) [CRISPR]: Positive Regulator (Hh signaling, neg_rank=657, lfc=-2.02) PMID:30270045

Subcellular localization

centrosome, cilia associated gene

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation

Function

WDR8. Centriolar satellite and centriole-associated protein. Interacts with centriolar satellite proteins SSX2IP and PCM1 and centriolar proximal end component Cep135. Promotes ciliary vesicle docking during ciliogenesis. (26675238).

Model organism evidence

Danio rerio (1 reference)

WDR8 is a centriolar protein that has important roles in centrosomal assembly, spindle pole formation and ciliogenesis.

PMIDs: 33693649