WT1

WT1 transcription factor

Ensembl:
ENSG00000184937
UniProt:
P19544
OMIM:
607102
Synonyms:
AWT1, GUD, NPHS4, WAGR, WIT-2

Cilia effects upon perturbation of WT1

Ciliogenesis screen results (4 screens)

  • Kim2016: No effect
  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: Hyper-ciliogenesis (robust z=2.77, ciliated=58.8%) PMID:26595381

Subcellular localization

basal body, nucleus

Functional category

  • Ciliary assembly/disassembly
  • Cardiac & muscle development
  • ECM & connective tissue
  • Transcription regulation

Function

Wtip sig ling in conjunction with WT1 is essential for proepicardial organ specification in the zebrafish heart ( 27484451).

Model organism evidence

Mus musculus (2 references)

Some genetic kidney diseases (CAKUT, ciliopathies, tubulopathies) that result in secondary forms of FSGS also h

In the present study, we demonstrate that wtip expression is identical in wt1a‑, tcf21‑, and tbx18‑positive PE cells, and that Wtip protein localizes to the basal body of PE cells.

PMIDs: 37578539, 27484451

Danio rerio (2 references)

Morpholino-mediated knockdown of intraflagellar transport protein Ift172 in Tg(wt1b:EGFP) embryos was used to induce large glomerular cysts representing a robustly scorable phenotypic readout.

In the present study, we demonstrate that wtip expression is identical in wt1a‑, tcf21‑, and tbx18‑positive PE cells, and that Wtip protein localizes to the basal body of PE cells.

PMIDs: 30875791, 27484451