WT1

WT1 transcription factor

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000184937
UniProt:
P19544
OMIM:
607102
Synonyms:
AWT1, GUD, NPHS4, WAGR, WIT-2, WT-1

Ciliogenesis screen results (4 screens)

  • Kim2016: No effect
  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: Hyper-ciliogenesis (robust z=2.77, ciliated=58.8%) PMID:26595381

Subcellular localization

basal body, nucleus

References: PMID:27484451

Functional category

  • Ciliary assembly/disassembly
  • Cardiac & muscle development
  • ECM & connective tissue
  • Transcription regulation

Function

Wtip signaling in conjunction with WT1 is essential for proepicardial organ specification in the zebrafish heart ( 27484451).