WTIP

WT1 interacting protein

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000142279
UniProt:: A6NIX2
OMIM:: 614790

Cilia effects upon perturbation of WTIP

Cilia number / % ciliated:: Decreased cilia number
Loss-of-function effect:: Shorter cilia

Ciliogenesis screen results (2 screens)

Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Phenotypes

Mouse phenotype:: preweaning lethality, incomplete penetrance

Subcellular localization

cilia, lysosomes, nucleus, p-body

References: PMID:27062996

Functional category

Ciliary assembly/disassembly
Actin & cytoskeleton regulation

Function

Pk3 may involve Wilms tumor protein 1-interacting protein (Wtip), which physically associates with and cooperates with Pk3 to regulate ciliogenesis(27062996).

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