WTIP
WT1 interacting protein
- Ensembl:
- ENSG00000142279
- UniProt:
- A6NIX2
- OMIM:
- 614790
Cilia effects upon perturbation of WTIP
- Cilia number / % ciliated:
- Decreased cilia number
- Loss-of-function effect:
- Shorter cilia
Ciliogenesis screen results (2 screens)
- Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
- Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Phenotypes
- Mouse phenotype:
- preweaning lethality, incomplete penetrance
Subcellular localization
cilia, lysosomes, nucleus, p-body
Functional category
- Ciliary assembly/disassembly
- Actin & cytoskeleton regulation
Function
Pk3 may involve Wilms tumor protein 1-interacting protein (Wtip), which physically associates with and cooperates with Pk3 to regulate ciliogenesis(27062996).
Model organism evidence
Wilms tumor-1-interacting protein (Wtip) is a LIM-domain-containing adaptor that links cell junctions with actomyosin complexes and modulates actomyosin contractility and ciliogenesis in Xenopus embryos.
Prickle3 synergizes with Wtip to regulate basal body organization and cilia growth.
In the present study, we demonstrate that wtip expression is identical in wt1a‑, tcf21‑, and tbx18‑positive PE cells, and that Wtip protein localizes to the basal body of PE cells.
Prickle3 synergizes with Wtip to regulate basal body organization and cilia growth.
In the present study, we demonstrate that wtip expression is identical in wt1a‑, tcf21‑, and tbx18‑positive PE cells, and that Wtip protein localizes to the basal body of PE cells.
Wtip is an LIM domain protein of the Ajuba/Zyxin family, but its role in ciliogenesis during embryonic development has not been previously described.
Prickle3 synergizes with Wtip to regulate basal body organization and cilia growth.
PMIDs: 27062996