WWP1
WW domain containing E3 ubiquitin protein ligase 1
- Ensembl:
- ENSG00000123124
- UniProt:
- Q9H0M0
- OMIM:
- 602307
- Synonyms:
- AIP5, DKFZP434D2111
Cilia effects upon perturbation of WWP1
- Cilia number / % ciliated:
- No effect
- Loss-of-function effect:
- No effect
Ciliogenesis screen results (4 screens)
- Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-6.90) PMID:26167766
- Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
- Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
- Pusapati et al. 2018 (CRISPR) [CRISPR]: Negative Regulator (Hh signaling, pos_rank=450, lfc=0.57) PMID:30270045
Phenotypes
- Mouse phenotype:
- decreased locomotor activity, decreased fasting circulating glucose level, increased circulating phosphate level
- Mouse ciliopathy phenotype:
- short tibia
Subcellular localization
cilia, cytosol, nucleus
Functional category
- Ciliary assembly/disassembly
- T cell biology
- Viral interactions
- Signaling (Hedgehog, GPCRs, ion channels)
- Transcription regulation
Function
The ciliary E3, Wwp1, binds Ptch1 and localizes to cilia at the basal state. Activation of sig ling removes both Ptch1 and Wwp1 from cilia, thus providing an elegant mechanism for Ptch1 to regulate ciliary Smo levels(34161574).