XAB2

XPA binding protein 2

Ensembl:
ENSG00000076924
UniProt:
Q9HCS7
OMIM:
610850
Synonyms:
HCNP, HCRN, NTC90, SYF1

Cilia effects upon perturbation of XAB2

Cilia number / % ciliated:
Decreased cilia number

Ciliogenesis screen results (4 screens)

  • Kim2016: Decreased cilia numbers
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-22.61) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: Increased Signaling (Negative Regulator) PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: Joubert Candidate / Ciliogenesis Defect (robust z=-3.42, ciliated=11.5%) PMID:26595381

Subcellular localization

cilia associated gene

Functional category

  • Ciliary assembly/disassembly

Function

The impact of mRNA splicing on cilia assembly after mitosis of the cell cycle. Splicing regulators SON and XAB2 play an important role in mitosis exit, and thus affect ciliogenesis in G1/G0 phases. The pivotal role of mRNA splicing regulators in cilia assembly and underscores the importance of mitotic regulation in ciliogenesis(PMID: 30460047).

Model organism evidence

Danio rerio (1 reference)

We demonstrate that splicing regulators such as SON and XAB2 play an important role in mitosis exit, and thus affect ciliogenesis in G1/G0 phases.

PMIDs: 30460047