XPO1

exportin 1

Ensembl:: ENSG00000082898
UniProt:: O14980
OMIM:: 602559
Synonyms:: CRM-1, CRM1, EMB

Cilia effects upon perturbation of XPO1

Ciliogenesis screen results (4 screens)

Kim2016: Not Reported
Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-3.02) PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: Increased Signaling (Negative Regulator) PMID:29459680
Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

cilia, cytosol, nucleus

Functional category

Ciliary assembly/disassembly
Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
Actin & cytoskeleton regulation
T cell biology
Viral interactions
Signaling (Hedgehog, GPCRs, ion channels)
Transcription regulation

Function

XPO1 has localized in cilia.

Model organism evidence

Mus musculus (2 references)

Temporospatial sonic hedgehog signalling is essential for neural crest-dependent patterning of the intrinsic tongue musculature.

Heterotrimeric kinesin-2 (KIF3) mediates transition zone and axoneme formation of mouse photoreceptors.

PMIDs: 31719045, 25825494

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