XPO1

exportin 1

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000082898
UniProt:
O14980
OMIM:
602559
Synonyms:
CRM-1, CRM1, EMB

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-3.02) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: Increased Signaling (Negative Regulator) PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

cilia, cytosol, nucleus, ciliary tip

References: PMID:41005307

Functional category

  • Ciliary assembly/disassembly
  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
  • Actin & cytoskeleton regulation
  • Viral interactions
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Transcription regulation

Function

XPO1 has localized in cilia.