YTHDF2

YTH N6-methyladenosine RNA binding protein F2

Ensembl:: ENSG00000198492
UniProt:: Q9Y5A9
OMIM:: 610640
Synonyms:: CAHL, HGRG8, NY-REN-2

Cilia effects upon perturbation of YTHDF2

Ciliogenesis screen results (4 screens)

Kim2016: No effect
Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

cilia associated gene, cytoplasmic bodies, cytosol

Functional category

Motile cilium & axoneme

Function

RIP results showed that YTH domain family 2 (YTHDF2) inhibited KMT2D level by binding to KMT2D mRNA. Si-YTHDF2 upregulated KMT2D expression and CYLD in LPS-induced tubal epithelial cells, increased cell viability and ciliary beat frequency, and inhibited YTHDF2, IL-1β, IL-6, IL-8, TNF-α, and MPO levels. Si-KMT2D interrupted si-YTHDF2 effect on LPS-induced rat tubal epithelial cells. In addition, si-YTHDF2 promoted KMT2D and CYLD expression in tubal tissue of TFI rats, increased the pregnancy rate and live birth rate, improved the degree of uterine and tubal lesions, and inhibited the serum levels of IL-1β, IL-6, IL-8, TNF-α, and MPO. Si-KMT2D reversed si-YTHDF2 effect on TFI rats(PMID: 41689730).

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