YWHAH

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta

Ensembl:
ENSG00000128245
UniProt:
Q04917
OMIM:
113508
Synonyms:
YWHA1

Cilia effects upon perturbation of YWHAH

Ciliogenesis screen results (4 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Pusapati et al. 2018 (CRISPR) [CRISPR]: Negative Regulator (Hh signaling, pos_rank=778, lfc=0.70) PMID:30270045

Subcellular localization

cilia, cytosol

Functional category

  • Ciliary assembly/disassembly
  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
  • Actin & cytoskeleton regulation
  • Neurogenesis & migration
  • Viral interactions
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Transcription regulation

Function

Crumbs-associated Par3/Par6/aPKC polarity cassette localizes to cilia and regulates ciliogenesis and there appears to be an important role for the polarity-regulating 14-3-3 proteins in this process (15324661).