ZC2HC1A
zinc finger C2HC-type containing 1A
- Ensembl:
- ENSG00000104427
- UniProt:
- Q96GY0
- Synonyms:
- C8ORF70, CGI-62, FAM164A
Cilia effects upon perturbation of ZC2HC1A
- Cilia number / % ciliated:
- Decreased cilia number
- Loss-of-function effect:
- No effect
- Overexpression effect:
- No effect
Ciliogenesis screen results (3 screens)
- Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-2.41) PMID:26167766
- Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
- Elliott et al. 2025 (CRISPRa) [CRISPRa]: Disassembly Trigger (casTLE Effect=-5.82) PMID:41160700
Phenotypes
- Mouse phenotype:
- abnormal eye morphology, abnormal skin morphology, abnormal freezing behavior, decreased exploration in new environment, increased freezing behavior
Subcellular localization
cilia
Functional category
- Ciliary assembly/disassembly
Function
ZC2HC1A localize to the cilia of sensory neurons of the head and tails in C. elegans(38989623).