ZC2HC1C

Cilia effects upon perturbation of ZC2HC1C

Ciliogenesis screen results (2 screens)

• Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
• Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Phenotypes

Mouse phenotype:

abnormal eye morphology, enlarged thymus, abnormal thymus morphology

Mouse ciliopathy phenotype:

enlarged testis, abnormal heart morphology, enlarged heart, hydrometra, abnormal testis morphology, abnormal uterus morphology, small testis, abnormal spine curvature, kyphosis

Subcellular localization

cilia

Functional category

• Ciliary assembly/disassembly

Function

ZC2HC1C localizes to ciliary tip domain and statio ry foci along the axoneme, positions of which coincide with sites of intraflagellar train pausing and turning.