ZC3H8

Ciliogenesis screen results (3 screens)

• Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
• Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
• Pusapati et al. 2018 (CRISPR) [CRISPR]: Positive Regulator (Hh signaling, neg_rank=164, lfc=-1.54) PMID:30270045

Phenotypes

Mouse phenotype:

abnormal skin morphology; lordosis; enlarged spleen; embryonic lethality prior to tooth bud stage; decreased CD8-positive; naive alpha-beta T cell number; preweaning lethality; complete penetrance; abnormal digit morphology; embryonic lethality prior to organogenesis; increased circulating total protein level; enlarged liver; abnormal spleen morphology

Subcellular localization

nuclear bodies, nucleoplasm

References: PMID:41291844

Function

Introduction of the SCNM1 WT protein into SCNM1−/− cells restored the expression of TMEM107, CIBAR1, DERL2, ZC3H8 and C17orf75, both at the transcript and protein levels, as well as the ciliary defects associated with the loss of SCNM1 (FPMID: 41291844).