ZCCHC8

zinc finger CCHC-type containing 8

Ensembl:
ENSG00000033030
UniProt:
Q6NZY4
OMIM:
616381
Synonyms:
DKFZP434E2220

Cilia effects upon perturbation of ZCCHC8

Ciliogenesis screen results (5 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Kim et al. 2010 (siRNA) [siRNA]: Longer Cilia (Area per Cilia z=3.48) PMID:20393562

Phenotypes

Human ciliopathy phenotype:
pulmonary fibrosis, and/or bone marrow failure, telomere-related, 5

Subcellular localization

cilia associated gene

Functional category

  • Ciliary assembly/disassembly
  • Protein processing & maturation

Function

Homozygous mice (Zcchc8-/-) develop a progressive and fatal neurodevelopmental pathology with features of a ciliopathy. These mice may be useful for studying telomerase RNA (TR) maturation and global RNA processing(PMID: 31488579).