ZDHHC5

zinc finger DHHC-type palmitoyltransferase 5

Ensembl:
ENSG00000156599
UniProt:
Q9C0B5
Synonyms:
DHHC5, KIAA1748, ZNF375

Cilia effects upon perturbation of ZDHHC5

Cilia number / % ciliated:
Little effect
Loss-of-function effect:
Longer cilia

Ciliogenesis screen results (5 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Kim et al. 2010 (siRNA) [siRNA]: Shorter Cilia (Area per Cilia z=-3.36) PMID:20393562

Phenotypes

Mouse phenotype:
shortened pr interval, decreased total reti thickness, increased mean platelet volume, decreased startle reflex
Mouse ciliopathy phenotype:
polycystic kidney, abnormal auditory brainstem response, abnormal reti vasculature morphology, abnormal reti morphology

Subcellular localization

cilia

Functional category

  • Ciliary assembly/disassembly
  • Viral interactions
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

ZDHHC5 has localized in cilia(40930094).