ZIC1

Zic family member 1

Tier: Cilia-Associated Genes

Ensembl:
ENSG00000152977
UniProt:
Q15915
OMIM:
600470
Synonyms:
ZIC, ZNF201

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Ciliopathy associations

  • Medulloblastoma

References: PMID:39753768

Subcellular localization

nucleus

References: PMID:20354137

Functional category

  • Ciliary assembly/disassembly
  • Transcription regulation

Function

Zic1, perhaps together with Gli1 and Gli3, may act as a link between mechanosensing and Wnt signaling ( 20354137).