ZNF474

Cilia effects upon perturbation of ZNF474

Cilia number / % ciliated:

No effect

Loss-of-function effect:

No effect

Overexpression effect:

No effect

Ciliogenesis screen results (2 screens)

• Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
• Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Phenotypes

Mouse phenotype:

increased eosinophil cell number, abnormal skin morphology, decreased lymphocyte cell number, abnormal digit morphology, increased red blood cell distribution width, increased neutrophil cell number

Mouse ciliopathy phenotype:

enlarged heart, abnormal heart morphology, abnormal testis morphology, small testis

Subcellular localization

cilia

Functional category

• Ciliary assembly/disassembly

Function

ZNF474 localize to the cilia of sensory neurons of the head and tails in C. elegans(38989623).