ZNF703

zinc finger protein 703

Ensembl:
ENSG00000183779
UniProt:
Q9H7S9
OMIM:
617045
Synonyms:
FLJ14299, NLZ1, ZEPPO1, ZNF503L, ZPO1

Cilia effects upon perturbation of ZNF703

Loss-of-function effect:
Shorter cilia

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Elliott et al. 2025 (CRISPRa) [CRISPRa]: Disassembly Trigger (casTLE Effect=-2.96) PMID:41160700

Subcellular localization

cilia associated gene, nucleus

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • Cell migration & adhesion
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Transcription regulation

Function

Nlz1 contributes to motile cilia formation by positively regulating Wnt11/presumed non-canonical Wnt sig ling ( 26327644).

Model organism evidence

Danio rerio (1 reference)

nlz1 is required for cilia formation in zebrafish embryogenesis.

PMIDs: 26327644