ZNF750

zinc finger protein 750

Ensembl:
ENSG00000141579
UniProt:
Q32MQ0
OMIM:
610226
Synonyms:
FLJ13841, ZFP750

Cilia effects upon perturbation of ZNF750

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Pusapati et al. 2018 (CRISPR) [CRISPR]: Negative Regulator (Hh signaling, pos_rank=391, lfc=0.65) PMID:30270045

Phenotypes

Mouse phenotype:
preweaning lethality, complete penetrance

Subcellular localization

cilia associated gene

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • Transcription regulation

Function

The genome editing of other putative target genes reveals roles for zinc finger transcription factor Znf750 and small membrane adhesion glycoprotein in promoting ciliogenesis and barrier function as part of a network of genes coordinately regulated by Grhl2(PMID: 26527742).