ZRSR2

zinc finger CCCH-type, RNA binding motif and serine/arginine rich 2

Ensembl:
ENSG00000169249
UniProt:
Q15696
OMIM:
300028
Synonyms:
U2AF1-RS2, U2AF1L2, URP, ZC3H22

Cilia effects upon perturbation of ZRSR2

Loss-of-function effect:
Longer cilia

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-3.68) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Pusapati et al. 2018 (CRISPR) [CRISPR]: Positive Regulator (Hh signaling, neg_rank=979, lfc=-0.78) PMID:30270045

Ciliopathy associations

  • Orofaciodigital Syndrome

Subcellular localization

cilia associated gene, nucleus

Functional category

  • Ciliary assembly/disassembly

Function

Mutations in the ZRSR2 gene cause Orofaciodigital Syndrome (PMID: 38158857).